Put the cream cheese in the freezer for 5 minutes to chill. Cut into 24 cubes.
In a mixing bowl, combine cornbread mix, milk, and egg. Fold in the hot dog pieces, jalapeño, and chilled cubed cream cheese, and mix.
Spray a mini-muffin tin (that can hold 24 mini-muffins) with nonstick cooking spray. Divide the cornbread mixture equally into the muffin cups. Bake for 15-20 minutes.